Researchers to produce anti-cancer drugs in yeast, according to a study published on December 7, 2018.
This study was conducted by researchers at the Technical University of Denmark. Senior Researcher at The Novo Nordisk Foundation Center for Biosustainability said that new alternative with new rules need to be developed to produce therapeutics for cancer patients or people suffering from mental illnesses in the future. He is the coordinator of a new big EU Horizon 2020 project called MIAMi.
MIAMi research project aims to provide an alternative production route to the pharmaceutical industry by using the cellular workhorse baker's yeast. As a beginning, researchers mapped biosynthetic pathways of the rare plant Rauvolfia serpentina with the common name Indian snakeroot. According to Chinese medicine, Indian snakeroots can produce molecules with anticancer effect. However, manufacturing the valuable compounds outside the plant is still not possible, as the biosynthetic pathways are unknown.
A biosynthetic pathway is a number of specific genes that code for enzymes, which synthesize a bio-molecule within the cell. The aim of the researchers was to insert the genes into yeast cells that will act as biological cell factories capable of producing large amounts of these specific therapeutic substances.
Michael Krogh Jensen said, â€œThe industry knows that they need to change, which these regulations are also a clear signal about. We do not expect to be able to manufacture the products within this project period so that they can compete with current processes, but the alternative is that companies in the future can't offer the same products to their customers.â€
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